pneumococcus indirectly mosaic genes encoding
modified penicillin-binding proteins (PSB). However, S. pneumonia was also developed >> << not-PBP mechanisms involved in resistance to penicillin. In this study
whole genome sequencing of resistant microorganisms were used to identify mutations involved
resistance to penicillin. We are consistently two S. pneumonia isolates selected for resistance to penicillin in vitro. Analysis of the genome showed that the preparation of six genes mutated in both mutants strattera no prescritpion. They included three PBP genes, and three-PBP genes, including the alleged iron
permease, spr1178. Nonsense-mutations in spr1178 always occurred in the first >> << stage of selection. Although the mutant increased resistance to penicillin,
input modified versions of PSB in penicillin-sensitive strain
serial conversion led to a strain with a minimal increase in resistance, so
involvement of other genes of resistance. Introduction by converting not-PBP
recurrent mutation does not increase resistance to penicillin, but the introduction
nonsense-mutation in the foreseeable iron permease spr1178 resulted in a reduction >> << accumulation of reactive oxygen species form after exposure to penicillin and other antibacterial
antibiotics as well. This study shows that the selection of resistance to penicillin in S. pneumonia
involves the acquisition of mutations providing access to antibiotics induced
accumulation of oxidants, leading to increased survival, which probably
allows selection of the main factors that determine resistance such as mutations in the PSB. .
No comments:
Post a Comment